Amyloid β oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4,5-bisphosphate

Amyloid β (Aβ) oligomer-induced aberrant neurotransmitter release is proposed to be a crucial early event leading to synapse dysfunction in Alzheimer’s disease (AD). In the present study, we report that the release probability (Pr) at the synapse between the Schaffer collateral (SC) and CA1 pyramida...

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Detalles Bibliográficos
Autores principales: He, Yang, Wei, Mengdi, Wu, Yan, Qin, Huaping, Li, Weinan, Ma, Xiaolin, Cheng, Jingjing, Ren, Jinshuai, Shen, Ye, Chen, Zhong, Sun, Binggui, Huang, Fu-De, Shen, Yi, Zhou, Yu-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416269/
https://www.ncbi.nlm.nih.gov/pubmed/30867420
http://dx.doi.org/10.1038/s41467-019-09114-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416269/
https://www.ncbi.nlm.nih.gov/pubmed/30867420
http://dx.doi.org/10.1038/s41467-019-09114-z

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