Low-dose pioglitazone can ameliorate learning and memory impairment in a mouse model of dementia by increasing LRP1 expression in the hippocampus

Amyloid-β (Aβ) accumulation in the brain is a pathological feature of Alzheimer’s disease (AD) and enhancing Aβ clearance is a potential therapeutic strategy. Pioglitazone is a peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist and is widely used to treat type 2 diabetes. We previously re...

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Detalles Bibliográficos
Autores principales: Seok, Hannah, Lee, Minyoung, Shin, Eugene, Yun, Mi Ra, Lee, Yong-ho, Moon, Jae Hoon, Kim, Eosu, Lee, Phil Hyu, Lee, Byung-Wan, Kang, Eun Seok, Lee, Hyun Chul, Cha, Bong Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416325/
https://www.ncbi.nlm.nih.gov/pubmed/30867485
http://dx.doi.org/10.1038/s41598-019-40736-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416325/
https://www.ncbi.nlm.nih.gov/pubmed/30867485
http://dx.doi.org/10.1038/s41598-019-40736-x

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