Combined congenic mapping and nuclease-based gene targeting for studying allele-specific effects of Tnfrsf9 within the Idd9.3 autoimmune diabetes locus

Rodent complex trait genetic studies involving a cross between two inbred strains are usually followed by congenic mapping to refine the loci responsible for the phenotype. However, progressing from a chromosomal region to the actual causal gene remains challenging because multiple polymorphic genes...

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Detalles Bibliográficos
Autores principales: Forsberg, Matthew H., Foda, Bardees, Serreze, David V., Chen, Yi-Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416332/
https://www.ncbi.nlm.nih.gov/pubmed/30867509
http://dx.doi.org/10.1038/s41598-019-40898-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416332/
https://www.ncbi.nlm.nih.gov/pubmed/30867509
http://dx.doi.org/10.1038/s41598-019-40898-8

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