Casein kinase II–dependent phosphorylation of DNA topoisomerase II suppresses the effect of a catalytic topo II inhibitor, ICRF-193, in fission yeast

DNA topoisomerase II (topo II) regulates the topological state of DNA and is necessary for DNA replication, transcription, and chromosome segregation. Topo II has essential functions in cell proliferation and therefore is a critical target of anticancer drugs. In this study, using Phos-tag SDS-PAGE...

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Detalles Bibliográficos
Autores principales: Nakazawa, Norihiko, Arakawa, Orie, Ebe, Masahiro, Yanagida, Mitsuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2019
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416453/
https://www.ncbi.nlm.nih.gov/pubmed/30635402
http://dx.doi.org/10.1074/jbc.RA118.004955

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416453/
https://www.ncbi.nlm.nih.gov/pubmed/30635402
http://dx.doi.org/10.1074/jbc.RA118.004955

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