Cargando…
HIV-1 and SIV Infection Are Associated with Early Loss of Lung Interstitial CD4+ T Cells and Dissemination of Pulmonary Tuberculosis
Lung interstitial CD4+ T cells are critical for protection against pulmonary infections, but the fate of this population during HIV-1 infection is not well described. We studied CD4+ T cells in the setting of HIV-1 infection in human lung tissue, humanized mice, and a Mycobacterium tuberculosis (Mtb...
Autores principales: | , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417097/ https://www.ncbi.nlm.nih.gov/pubmed/30726727 http://dx.doi.org/10.1016/j.celrep.2019.01.021 |
_version_ | 1783403497876619264 |
---|---|
author | Corleis, Björn Bucsan, Allison N. Deruaz, Maud Vrbanac, Vladimir D. Lisanti-Park, Antonella C. Gates, Samantha J. Linder, Alice H. Paer, Jeffrey M. Olson, Gregory S. Bowman, Brittany A. Schiff, Abigail E. Medoff, Benjamin D. Tager, Andrew M. Luster, Andrew D. Khader, Shabaana A. Kaushal, Deepak Kwon, Douglas S. |
author_facet | Corleis, Björn Bucsan, Allison N. Deruaz, Maud Vrbanac, Vladimir D. Lisanti-Park, Antonella C. Gates, Samantha J. Linder, Alice H. Paer, Jeffrey M. Olson, Gregory S. Bowman, Brittany A. Schiff, Abigail E. Medoff, Benjamin D. Tager, Andrew M. Luster, Andrew D. Khader, Shabaana A. Kaushal, Deepak Kwon, Douglas S. |
author_sort | Corleis, Björn |
collection | PubMed |
description | Lung interstitial CD4+ T cells are critical for protection against pulmonary infections, but the fate of this population during HIV-1 infection is not well described. We studied CD4+ T cells in the setting of HIV-1 infection in human lung tissue, humanized mice, and a Mycobacterium tuberculosis (Mtb)/simian immunodeficiency virus (SIV) nonhuman primate co-infection model. Infection with a CCR5-tropic strain of HIV-1 or SIV results in severe and rapid loss of lung interstitial CD4+ T cells but not blood or lung alveolar CD4+ T cells. This is accompanied by high HIV-1 production in these cells in vitro and in vivo. Importantly, during early SIV infection, loss of lung interstitial CD4+ T cells is associated with increased dissemination of pulmonary Mtb infection. We show that lung interstitial CD4+ T cells serve as an efficient target for HIV-1 and SIV infection that leads to their early depletion and an increased risk of disseminated tuberculosis. |
format | Online Article Text |
id | pubmed-6417097 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
record_format | MEDLINE/PubMed |
spelling | pubmed-64170972019-03-14 HIV-1 and SIV Infection Are Associated with Early Loss of Lung Interstitial CD4+ T Cells and Dissemination of Pulmonary Tuberculosis Corleis, Björn Bucsan, Allison N. Deruaz, Maud Vrbanac, Vladimir D. Lisanti-Park, Antonella C. Gates, Samantha J. Linder, Alice H. Paer, Jeffrey M. Olson, Gregory S. Bowman, Brittany A. Schiff, Abigail E. Medoff, Benjamin D. Tager, Andrew M. Luster, Andrew D. Khader, Shabaana A. Kaushal, Deepak Kwon, Douglas S. Cell Rep Article Lung interstitial CD4+ T cells are critical for protection against pulmonary infections, but the fate of this population during HIV-1 infection is not well described. We studied CD4+ T cells in the setting of HIV-1 infection in human lung tissue, humanized mice, and a Mycobacterium tuberculosis (Mtb)/simian immunodeficiency virus (SIV) nonhuman primate co-infection model. Infection with a CCR5-tropic strain of HIV-1 or SIV results in severe and rapid loss of lung interstitial CD4+ T cells but not blood or lung alveolar CD4+ T cells. This is accompanied by high HIV-1 production in these cells in vitro and in vivo. Importantly, during early SIV infection, loss of lung interstitial CD4+ T cells is associated with increased dissemination of pulmonary Mtb infection. We show that lung interstitial CD4+ T cells serve as an efficient target for HIV-1 and SIV infection that leads to their early depletion and an increased risk of disseminated tuberculosis. 2019-02-05 /pmc/articles/PMC6417097/ /pubmed/30726727 http://dx.doi.org/10.1016/j.celrep.2019.01.021 Text en This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Corleis, Björn Bucsan, Allison N. Deruaz, Maud Vrbanac, Vladimir D. Lisanti-Park, Antonella C. Gates, Samantha J. Linder, Alice H. Paer, Jeffrey M. Olson, Gregory S. Bowman, Brittany A. Schiff, Abigail E. Medoff, Benjamin D. Tager, Andrew M. Luster, Andrew D. Khader, Shabaana A. Kaushal, Deepak Kwon, Douglas S. HIV-1 and SIV Infection Are Associated with Early Loss of Lung Interstitial CD4+ T Cells and Dissemination of Pulmonary Tuberculosis |
title | HIV-1 and SIV Infection Are Associated with Early Loss of Lung Interstitial CD4+ T Cells and Dissemination of Pulmonary Tuberculosis |
title_full | HIV-1 and SIV Infection Are Associated with Early Loss of Lung Interstitial CD4+ T Cells and Dissemination of Pulmonary Tuberculosis |
title_fullStr | HIV-1 and SIV Infection Are Associated with Early Loss of Lung Interstitial CD4+ T Cells and Dissemination of Pulmonary Tuberculosis |
title_full_unstemmed | HIV-1 and SIV Infection Are Associated with Early Loss of Lung Interstitial CD4+ T Cells and Dissemination of Pulmonary Tuberculosis |
title_short | HIV-1 and SIV Infection Are Associated with Early Loss of Lung Interstitial CD4+ T Cells and Dissemination of Pulmonary Tuberculosis |
title_sort | hiv-1 and siv infection are associated with early loss of lung interstitial cd4+ t cells and dissemination of pulmonary tuberculosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417097/ https://www.ncbi.nlm.nih.gov/pubmed/30726727 http://dx.doi.org/10.1016/j.celrep.2019.01.021 |
work_keys_str_mv | AT corleisbjorn hiv1andsivinfectionareassociatedwithearlylossoflunginterstitialcd4tcellsanddisseminationofpulmonarytuberculosis AT bucsanallisonn hiv1andsivinfectionareassociatedwithearlylossoflunginterstitialcd4tcellsanddisseminationofpulmonarytuberculosis AT deruazmaud hiv1andsivinfectionareassociatedwithearlylossoflunginterstitialcd4tcellsanddisseminationofpulmonarytuberculosis AT vrbanacvladimird hiv1andsivinfectionareassociatedwithearlylossoflunginterstitialcd4tcellsanddisseminationofpulmonarytuberculosis AT lisantiparkantonellac hiv1andsivinfectionareassociatedwithearlylossoflunginterstitialcd4tcellsanddisseminationofpulmonarytuberculosis AT gatessamanthaj hiv1andsivinfectionareassociatedwithearlylossoflunginterstitialcd4tcellsanddisseminationofpulmonarytuberculosis AT linderaliceh hiv1andsivinfectionareassociatedwithearlylossoflunginterstitialcd4tcellsanddisseminationofpulmonarytuberculosis AT paerjeffreym hiv1andsivinfectionareassociatedwithearlylossoflunginterstitialcd4tcellsanddisseminationofpulmonarytuberculosis AT olsongregorys hiv1andsivinfectionareassociatedwithearlylossoflunginterstitialcd4tcellsanddisseminationofpulmonarytuberculosis AT bowmanbrittanya hiv1andsivinfectionareassociatedwithearlylossoflunginterstitialcd4tcellsanddisseminationofpulmonarytuberculosis AT schiffabigaile hiv1andsivinfectionareassociatedwithearlylossoflunginterstitialcd4tcellsanddisseminationofpulmonarytuberculosis AT medoffbenjamind hiv1andsivinfectionareassociatedwithearlylossoflunginterstitialcd4tcellsanddisseminationofpulmonarytuberculosis AT tagerandrewm hiv1andsivinfectionareassociatedwithearlylossoflunginterstitialcd4tcellsanddisseminationofpulmonarytuberculosis AT lusterandrewd hiv1andsivinfectionareassociatedwithearlylossoflunginterstitialcd4tcellsanddisseminationofpulmonarytuberculosis AT khadershabaanaa hiv1andsivinfectionareassociatedwithearlylossoflunginterstitialcd4tcellsanddisseminationofpulmonarytuberculosis AT kaushaldeepak hiv1andsivinfectionareassociatedwithearlylossoflunginterstitialcd4tcellsanddisseminationofpulmonarytuberculosis AT kwondouglass hiv1andsivinfectionareassociatedwithearlylossoflunginterstitialcd4tcellsanddisseminationofpulmonarytuberculosis |