Persistent motor dysfunction despite homeostatic rescue of cerebellar morphogenesis in the Car8 waddles mutant mouse

BACKGROUND: Purkinje cells play a central role in establishing the cerebellar circuit. Accordingly, disrupting Purkinje cell development impairs cerebellar morphogenesis and motor function. In the Car8(wdl) mouse model of hereditary ataxia, severe motor deficits arise despite the cerebellum overcomi...

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Detalles Bibliográficos
Autores principales: Miterko, Lauren N., White, Joshua J., Lin, Tao, Brown, Amanda M., O’Donovan, Kevin J., Sillitoe, Roy V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417138/
https://www.ncbi.nlm.nih.gov/pubmed/30867000
http://dx.doi.org/10.1186/s13064-019-0130-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417138/
https://www.ncbi.nlm.nih.gov/pubmed/30867000
http://dx.doi.org/10.1186/s13064-019-0130-4

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