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Proteomics of the corpus callosum to identify novel factors involved in hypomyelinated Niemann-Pick Type C disease mice

Hypomyelination in the central nerves system (CNS) is one of the most obviously pathological features in Niemann-Pick Type C disease (NPC), which is a rare neurodegenerative disorder caused by mutations in the NPC intracellular cholesterol transporter 1 or 2 (Npc1 or Npc2). Npc1 plays key roles in b...

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Detalles Bibliográficos
Autores principales: Yang, Fan, Guan, Yudong, Feng, Xiao, Rolfs, Arndt, Schlüter, Hartmut, Luo, Jiankai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417209/
https://www.ncbi.nlm.nih.gov/pubmed/30866987
http://dx.doi.org/10.1186/s13041-019-0440-9