Molecular mechanisms of cisplatin-induced nephrotoxicity: a balance on the knife edge between renoprotection and tumor toxicity

BACKGROUND: Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe side effects, including nephrotoxicity and acute kidney injury (AKI) which develop due to renal accumulation and biotransformatio...

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Detalles Bibliográficos
Autores principales: Volarevic, Vladislav, Djokovic, Bojana, Jankovic, Marina Gazdic, Harrell, C. Randall, Fellabaum, Crissy, Djonov, Valentin, Arsenijevic, Nebojsa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417243/
https://www.ncbi.nlm.nih.gov/pubmed/30866950
http://dx.doi.org/10.1186/s12929-019-0518-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417243/
https://www.ncbi.nlm.nih.gov/pubmed/30866950
http://dx.doi.org/10.1186/s12929-019-0518-9

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