Aggressive Primary Pediatric Intracranial Malignant Melanoma: Sphinx of the Tissue Diagnosis

It is often intriguing to suspect and confirm the diagnosis of primary malignant melanoma (PMM) in the brain without any evidence of neurocutaneous melanosis. We report a 16-year-old male patient with malignant melanoma which intraoperatively was small sized, soft, fleshy, hemorrhagic in appearance...

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Autores principales: Sivaraju, Laxminadh, Ghosal, Nandita, Mahadevan, Anita, Uday Krishna, A. S., Rao, Shilpa, Hegde, Alangar S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417341/
https://www.ncbi.nlm.nih.gov/pubmed/30937053
http://dx.doi.org/10.4103/ajns.AJNS_253_17
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author Sivaraju, Laxminadh
Ghosal, Nandita
Mahadevan, Anita
Uday Krishna, A. S.
Rao, Shilpa
Hegde, Alangar S
author_facet Sivaraju, Laxminadh
Ghosal, Nandita
Mahadevan, Anita
Uday Krishna, A. S.
Rao, Shilpa
Hegde, Alangar S
author_sort Sivaraju, Laxminadh
collection PubMed
description It is often intriguing to suspect and confirm the diagnosis of primary malignant melanoma (PMM) in the brain without any evidence of neurocutaneous melanosis. We report a 16-year-old male patient with malignant melanoma which intraoperatively was small sized, soft, fleshy, hemorrhagic in appearance resembling hematoma. Interestingly, the histopathology showed prominent papillary architecture with a differential diagnosis of papillary meningioma and ependymoma and perplexed the tissue diagnosis. This case is discussed in light of very uncommon occurrence of intracranial PMM in pediatric age group, enigmatic histological features, and aggressive nature of lesion with rapid progression despite complete excision following radiation therapy.
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spelling pubmed-64173412019-04-01 Aggressive Primary Pediatric Intracranial Malignant Melanoma: Sphinx of the Tissue Diagnosis Sivaraju, Laxminadh Ghosal, Nandita Mahadevan, Anita Uday Krishna, A. S. Rao, Shilpa Hegde, Alangar S Asian J Neurosurg Case Report It is often intriguing to suspect and confirm the diagnosis of primary malignant melanoma (PMM) in the brain without any evidence of neurocutaneous melanosis. We report a 16-year-old male patient with malignant melanoma which intraoperatively was small sized, soft, fleshy, hemorrhagic in appearance resembling hematoma. Interestingly, the histopathology showed prominent papillary architecture with a differential diagnosis of papillary meningioma and ependymoma and perplexed the tissue diagnosis. This case is discussed in light of very uncommon occurrence of intracranial PMM in pediatric age group, enigmatic histological features, and aggressive nature of lesion with rapid progression despite complete excision following radiation therapy. Medknow Publications & Media Pvt Ltd 2019 /pmc/articles/PMC6417341/ /pubmed/30937053 http://dx.doi.org/10.4103/ajns.AJNS_253_17 Text en Copyright: © 2018 Asian Journal of Neurosurgery http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Sivaraju, Laxminadh
Ghosal, Nandita
Mahadevan, Anita
Uday Krishna, A. S.
Rao, Shilpa
Hegde, Alangar S
Aggressive Primary Pediatric Intracranial Malignant Melanoma: Sphinx of the Tissue Diagnosis
title Aggressive Primary Pediatric Intracranial Malignant Melanoma: Sphinx of the Tissue Diagnosis
title_full Aggressive Primary Pediatric Intracranial Malignant Melanoma: Sphinx of the Tissue Diagnosis
title_fullStr Aggressive Primary Pediatric Intracranial Malignant Melanoma: Sphinx of the Tissue Diagnosis
title_full_unstemmed Aggressive Primary Pediatric Intracranial Malignant Melanoma: Sphinx of the Tissue Diagnosis
title_short Aggressive Primary Pediatric Intracranial Malignant Melanoma: Sphinx of the Tissue Diagnosis
title_sort aggressive primary pediatric intracranial malignant melanoma: sphinx of the tissue diagnosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417341/
https://www.ncbi.nlm.nih.gov/pubmed/30937053
http://dx.doi.org/10.4103/ajns.AJNS_253_17
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