Aggressive Primary Pediatric Intracranial Malignant Melanoma: Sphinx of the Tissue Diagnosis
It is often intriguing to suspect and confirm the diagnosis of primary malignant melanoma (PMM) in the brain without any evidence of neurocutaneous melanosis. We report a 16-year-old male patient with malignant melanoma which intraoperatively was small sized, soft, fleshy, hemorrhagic in appearance...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417341/ https://www.ncbi.nlm.nih.gov/pubmed/30937053 http://dx.doi.org/10.4103/ajns.AJNS_253_17 |
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author | Sivaraju, Laxminadh Ghosal, Nandita Mahadevan, Anita Uday Krishna, A. S. Rao, Shilpa Hegde, Alangar S |
author_facet | Sivaraju, Laxminadh Ghosal, Nandita Mahadevan, Anita Uday Krishna, A. S. Rao, Shilpa Hegde, Alangar S |
author_sort | Sivaraju, Laxminadh |
collection | PubMed |
description | It is often intriguing to suspect and confirm the diagnosis of primary malignant melanoma (PMM) in the brain without any evidence of neurocutaneous melanosis. We report a 16-year-old male patient with malignant melanoma which intraoperatively was small sized, soft, fleshy, hemorrhagic in appearance resembling hematoma. Interestingly, the histopathology showed prominent papillary architecture with a differential diagnosis of papillary meningioma and ependymoma and perplexed the tissue diagnosis. This case is discussed in light of very uncommon occurrence of intracranial PMM in pediatric age group, enigmatic histological features, and aggressive nature of lesion with rapid progression despite complete excision following radiation therapy. |
format | Online Article Text |
id | pubmed-6417341 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-64173412019-04-01 Aggressive Primary Pediatric Intracranial Malignant Melanoma: Sphinx of the Tissue Diagnosis Sivaraju, Laxminadh Ghosal, Nandita Mahadevan, Anita Uday Krishna, A. S. Rao, Shilpa Hegde, Alangar S Asian J Neurosurg Case Report It is often intriguing to suspect and confirm the diagnosis of primary malignant melanoma (PMM) in the brain without any evidence of neurocutaneous melanosis. We report a 16-year-old male patient with malignant melanoma which intraoperatively was small sized, soft, fleshy, hemorrhagic in appearance resembling hematoma. Interestingly, the histopathology showed prominent papillary architecture with a differential diagnosis of papillary meningioma and ependymoma and perplexed the tissue diagnosis. This case is discussed in light of very uncommon occurrence of intracranial PMM in pediatric age group, enigmatic histological features, and aggressive nature of lesion with rapid progression despite complete excision following radiation therapy. Medknow Publications & Media Pvt Ltd 2019 /pmc/articles/PMC6417341/ /pubmed/30937053 http://dx.doi.org/10.4103/ajns.AJNS_253_17 Text en Copyright: © 2018 Asian Journal of Neurosurgery http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Case Report Sivaraju, Laxminadh Ghosal, Nandita Mahadevan, Anita Uday Krishna, A. S. Rao, Shilpa Hegde, Alangar S Aggressive Primary Pediatric Intracranial Malignant Melanoma: Sphinx of the Tissue Diagnosis |
title | Aggressive Primary Pediatric Intracranial Malignant Melanoma: Sphinx of the Tissue Diagnosis |
title_full | Aggressive Primary Pediatric Intracranial Malignant Melanoma: Sphinx of the Tissue Diagnosis |
title_fullStr | Aggressive Primary Pediatric Intracranial Malignant Melanoma: Sphinx of the Tissue Diagnosis |
title_full_unstemmed | Aggressive Primary Pediatric Intracranial Malignant Melanoma: Sphinx of the Tissue Diagnosis |
title_short | Aggressive Primary Pediatric Intracranial Malignant Melanoma: Sphinx of the Tissue Diagnosis |
title_sort | aggressive primary pediatric intracranial malignant melanoma: sphinx of the tissue diagnosis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417341/ https://www.ncbi.nlm.nih.gov/pubmed/30937053 http://dx.doi.org/10.4103/ajns.AJNS_253_17 |
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