Loss of TREM2 function increases amyloid seeding but reduces plaque associated ApoE

Coding variants in the triggering receptor expressed on myeloid cells 2 (TREM2) are associated with late onset Alzheimer’s disease (AD). We demonstrate that amyloid plaque seeding is increased in the absence of functional Trem2. Increased seeding is accompanied by decreased microglial clustering aro...

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Detalles Bibliográficos
Autores principales: Parhizkar, Samira, Arzberger, Thomas, Brendel, Matthias, Kleinberger, Gernot, Deussing, Maximilian, Focke, Carola, Nuscher, Brigitte, Xiong, Monica, Ghasemigharagoz, Alireza, Katzmarski, Natalie, Krasemann, Susanne, Lichtenthaler, Stefan F., Müller, Stephan A., Colombo, Alessio, Monasor, Laura Sebastian, Tahirovic, Sabina, Herms, Jochen, Willem, Michael, Pettkus, Nadine, Butovsky, Oleg, Bartenstein, Peter, Edbauer, Dieter, Rominger, Axel, Ertürk, Ali, Grathwohl, Stefan A., Neher, Jonas J, Holtzman, David M., Meyer-Luehmann, Melanie, Haass, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417433/
https://www.ncbi.nlm.nih.gov/pubmed/30617257
http://dx.doi.org/10.1038/s41593-018-0296-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417433/
https://www.ncbi.nlm.nih.gov/pubmed/30617257
http://dx.doi.org/10.1038/s41593-018-0296-9

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