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Blocking skeletal muscle DHPRs/Ryr1 prevents neuromuscular synapse loss in mutant mice deficient in type III Neuregulin 1 (CRD-Nrg1)
Schwann cells are integral components of vertebrate neuromuscular synapses; in their absence, pre-synaptic nerve terminals withdraw from post-synaptic muscles, leading to muscle denervation and synapse loss at the developing neuromuscular junction (NMJ). Here, we report a rescue of muscle denervatio...
Autores principales: | Liu, Yun, Sugiura, Yoshie, Chen, Fujun, Lee, Kuo-Fen, Ye, Qiaohong, Lin, Weichun |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417856/ https://www.ncbi.nlm.nih.gov/pubmed/30870432 http://dx.doi.org/10.1371/journal.pgen.1007857 |
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