Cargando…

Whole genome sequencing identifies high-impact variants in well-known pharmacogenomic genes

More than 1,100 genetic loci have been correlated with drug response outcomes but disproportionately few have been translated into clinical practice. One explanation for the low rate of clinical implementation is that the majority of associated variants may be in linkage disequilibrium (LD) with the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Choi, Jihoon, Tantisira, Kelan G., Duan, Qing Ling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417988/ https://www.ncbi.nlm.nih.gov/pubmed/30214008 http://dx.doi.org/10.1038/s41397-018-0048-y

Ejemplares similares

Genome-Wide Association Study Identifies Novel Pharmacogenomic Loci For Therapeutic Response to Montelukast in Asthma
por: Dahlin, Amber, et al.
Publicado: (2015)

Whole genome sequencing in pharmacogenomics
por: Katsila, Theodora, et al.
Publicado: (2015)

Identification of deleterious and regulatory genomic variations in known asthma loci
por: Neville, Matthew D. C., et al.
Publicado: (2018)

Utilization of Whole Exome Sequencing Data to Identify Clinically Relevant Pharmacogenomic Variants in Pediatric Inflammatory Bowel Disease
por: Mulder, Daniel J., et al.
Publicado: (2020)

Characterization of pharmacogenomic variants in a Brazilian admixed cohort of elderly individuals based on whole-genome sequencing data
por: Bertholim-Nasciben, Luciana, et al.
Publicado: (2023)

Screening of whole genome sequences identified high-impact variants for stallion fertility
por: Schrimpf, Rahel, et al.
Publicado: (2016)

Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing
por: Floyd, James S., et al.
Publicado: (2019)

Pharmacogenomic landscape of Indian population using whole genomes
por: Sahana, S., et al.
Publicado: (2022)

The well-known and less well-known benefits of vaccines
por: Michel, Jean-Pierre
Publicado: (2020)

Handover of the Editor in Chief positions – from the new Editors-in-Chief to the readership of Respiratory Research
por: Tantisira, Kelan, et al.
Publicado: (2019)

A high-throughput chemical screen identifies novel inhibitors and enhancers of anti-inflammatory functions of the glucocorticoid receptor
por: Jiang, Xiaofeng, et al.
Publicado: (2017)

Genetic analysis of osteopetrosis in Pakistani families identifies novel and known sequence variants
por: Liu, Chunyu, et al.
Publicado: (2021)

Pathogenic variants in KPTN gene identified by clinical whole-genome sequencing
por: Thiffault, Isabelle, et al.
Publicado: (2020)

Childhood infections and asthma: at the crossroads of the hygiene and Barker hypotheses
por: Tantisira, Kelan G, et al.
Publicado: (2001)

Whole-exome sequencing identified genes known to be responsible for retinitis pigmentosa in 28 Chinese families
por: Shen, Chang, et al.
Publicado: (2022)

Lung function, airway and peripheral basophils and eosinophils are associated with molecular pharmacogenomic endotypes of steroid response in severe asthma
por: Kho, Alvin T, et al.
Publicado: (2022)

Whole genome prediction and heritability of childhood asthma phenotypes
por: McGeachie, Michael J., et al.
Publicado: (2016)

Whole-genome sequencing of two probands with hereditary spastic paraplegia reveals novel splice-donor region variant and known pathogenic variant in SPG11
por: Yu, Allen Chi-Shing, et al.
Publicado: (2016)

Genetic Signatures of Asthma Exacerbation
por: Park, Heung-Woo, et al.
Publicado: (2017)

Whole genome sequencing identifies genetic variants associated with neurogenic inflammation in rosacea
por: Deng, Zhili, et al.
Publicado: (2023)

PlasmidSeeker: identification of known plasmids from bacterial whole genome sequencing reads
por: Roosaare, Märt, et al.
Publicado: (2018)

Pharmacogenomic findings from clinical whole exome sequencing of diagnostic odyssey patients
por: Cousin, Margot A., et al.
Publicado: (2017)

Whole Exome Sequencing Reveals Clustering of Variants of Known Vitiligo Genes in Multiplex Consanguineous Pakistani Families
por: Ishaq, Rafaqat, et al.
Publicado: (2023)

Whole-Exome Sequencing Identifies a Novel Genotype-Phenotype Correlation in the Entactin Domain of the Known Deafness Gene TECTA
por: Choi, Byung Yoon, et al.
Publicado: (2014)

Whole genome sequencing in support of wellness and health maintenance
por: Patel, Chirag J, et al.
Publicado: (2013)

Pharmacogenomics of Novel Direct Oral Anticoagulants: Newly Identified Genes and Genetic Variants
por: Kanuri, Sri H., et al.
Publicado: (2019)

Whole genome sequencing identifies rare genetic variants in familial pancreatic cancer patients
por: Tan, Ming, et al.
Publicado: (2022)

On Unrooted and Root-Uncertain Variants of Several Well-Known Phylogenetic Network Problems
por: van Iersel, Leo, et al.
Publicado: (2017)

Analysis of population-specific pharmacogenomic variants using next-generation sequencing data
por: Ahn, Eunyong, et al.
Publicado: (2017)

Using machine learning to improve our understanding of COVID-19 infection in children
por: Piparia, Shraddha, et al.
Publicado: (2023)

Systematic Pharmacogenomics Analysis of a Malay Whole Genome: Proof of Concept for Personalized Medicine
por: Salleh, Mohd Zaki, et al.
Publicado: (2013)

Application of Whole Exome Sequencing to Identify Disease-Causing Variants in Inherited Human Diseases
por: Goh, Gerald, et al.
Publicado: (2012)

Whole genome sequencing identifies structural variants contributing to hematologic traits in the NHLBI TOPMed program
por: Wheeler, Marsha M., et al.
Publicado: (2022)

Whole-genome sequencing of glioblastoma reveals enrichment of non-coding constraint mutations in known and novel genes
por: Sakthikumar, Sharadha, et al.
Publicado: (2020)

Whole-genome sequencing as an investigational device for return of hereditary disease risk and pharmacogenomic results as part of the All of Us Research Program
por: Venner, Eric, et al.
Publicado: (2022)

Detecting disease-associated genomic outcomes using constrained mixture of Bayesian hierarchical models for paired data
por: Li, Yunfeng, et al.
Publicado: (2017)

Whole-exome sequencing identifies variants in invasive pituitary adenomas
por: Lan, Xiaolei, et al.
Publicado: (2016)

Whole-exome sequencing analysis identifies novel variants associated with Kawasaki disease susceptibility
por: Zhang, Xing, et al.
Publicado: (2023)

Novel Alzheimer’s disease risk variants identified based on whole-genome sequencing of APOE ε4 carriers
por: Park, Jong-Ho, et al.
Publicado: (2021)

Fast read alignment with incorporation of known genomic variants
por: Guo, Hongzhe, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ecqntassfvsmogutsr31oglpto