A mouse model featuring tissue-specific deletion of p53 and Brca1 gives rise to mammary tumors with genomic and transcriptomic similarities to human basal-like breast cancer

PURPOSE AND METHODS: In human basal-like breast cancer, mutations and deletions in TP53 and BRCA1 are frequent oncogenic events. Thus, we interbred mice expressing the CRE-recombinase with mice harboring loxP sites at TP53 and BRCA1 (K14-Cre; p53(f/f) Brca1(f/f)) to test the hypothesis that tissue-s...

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Detalles Bibliográficos
Autores principales: Hollern, Daniel P., Contreras, Cristina M., Dance-Barnes, Stephanie, Silva, Grace O., Pfefferle, Adam D., Xiong, Jessie, Darr, David B., Usary, Jerry, Mott, Kevin R., Perou, Charles M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Preclinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418066/
https://www.ncbi.nlm.nih.gov/pubmed/30484104
http://dx.doi.org/10.1007/s10549-018-5061-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418066/
https://www.ncbi.nlm.nih.gov/pubmed/30484104
http://dx.doi.org/10.1007/s10549-018-5061-y

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