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Solution structure of the RNA recognition domain of METTL3-METTL14 N(6)-methyladenosine methyltransferase
N(6)-methyladenosine (m(6)A), a ubiquitous RNA modification, is installed by METTL3-METTL14 complex. The structure of the heterodimeric complex between the methyltransferase domains (MTDs) of METTL3 and METTL14 has been previously determined. However, the MTDs alone possess no enzymatic activity. He...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Higher Education Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418081/ https://www.ncbi.nlm.nih.gov/pubmed/29542011 http://dx.doi.org/10.1007/s13238-018-0518-7 |