Differential transactivation of the upstream aggrecan enhancer regulated by PAX1/9 depends on SOX9-driven transactivation

A previously identified enhancer 10 kb upstream of the Aggrecan (Acan) gene (UE) can drive cartilage specific reporter expression in vivo. Here, we report that the paralogous transcription factors PAX1 and PAX9 differentially drive UE, depending on the presence or absence of SOX9-driven transactivat...

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Detalles Bibliográficos
Autores principales: Takimoto, Aki, Kokubu, Chikara, Watanabe, Hitomi, Sakuma, Tetsushi, Yamamoto, Takashi, Kondoh, Gen, Hiraki, Yuji, Shukunami, Chisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418084/
https://www.ncbi.nlm.nih.gov/pubmed/30872687
http://dx.doi.org/10.1038/s41598-019-40810-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418084/
https://www.ncbi.nlm.nih.gov/pubmed/30872687
http://dx.doi.org/10.1038/s41598-019-40810-4

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