UHPLC-MS/MS method for analysis of sobuzoxane, its active form ICRF-154 and metabolite EDTA-diamide and its application to bioactivation study

Sobuzoxane (MST-16) is an approved anticancer agent, a pro-drug of bisdioxopiperazine analog ICRF-154. Due to the structural similarity of ICRF-154 to dexrazoxane (ICRF-187), MST-16 deserves attention as a cardioprotective drug. This study presents for the first time UHPLC-MS/MS assay of MST-16, ICR...

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Detalles Bibliográficos
Autores principales: Reimerová, Petra, Jirkovská, Anna, Piskáčková, Hana Bavlovič, Karabanovich, Galina, Roh, Jaroslav, Šimůnek, Tomáš, Štěrbová-Kovaříková, Petra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418109/
https://www.ncbi.nlm.nih.gov/pubmed/30872754
http://dx.doi.org/10.1038/s41598-019-40928-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418109/
https://www.ncbi.nlm.nih.gov/pubmed/30872754
http://dx.doi.org/10.1038/s41598-019-40928-5

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