Systemic LPS-induced Aβ-solubilization and clearance in AβPP-transgenic mice is diminished by heparanase overexpression

Amyloid-β (Aβ) is the main constituent of amyloid deposits in Alzheimer’s disease (AD). The neuropathology is associated with neuroinflammation. Here, we investigated effects of systemic lipopolysaccharide (LPS)-treatment on neuroinflammation and Aβ deposition in AβPP-mice and double-transgenic mice...

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Detalles Bibliográficos
Autores principales: Jendresen, Charlotte, Digre, Andreas, Cui, Hao, Zhang, Xiao, Vlodavsky, Israel, Li, Jin-Ping, Nilsson, Lars N. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418119/
https://www.ncbi.nlm.nih.gov/pubmed/30872722
http://dx.doi.org/10.1038/s41598-019-40999-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418119/
https://www.ncbi.nlm.nih.gov/pubmed/30872722
http://dx.doi.org/10.1038/s41598-019-40999-4

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