Probing Membrane Association of α-Synuclein Domains with VDAC Nanopore Reveals Unexpected Binding Pattern

It is well established that α-synuclein (α-syn) binding from solution to the surface of membranes composed of negatively charged and/or non-lamellar lipids can be characterized by equilibrium dissociation constants of tens of micromolar. Previously, we have found that a naturally occurring nanopore...

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Detalles Bibliográficos
Autores principales: Jacobs, Daniel, Hoogerheide, David P., Rovini, Amandine, Jiang, Zhiping, Lee, Jennifer C., Rostovtseva, Tatiana K., Bezrukov, Sergey M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418135/
https://www.ncbi.nlm.nih.gov/pubmed/30872688
http://dx.doi.org/10.1038/s41598-019-40979-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418135/
https://www.ncbi.nlm.nih.gov/pubmed/30872688
http://dx.doi.org/10.1038/s41598-019-40979-8

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