Rapid and reversible suppression of ALT by DAXX in osteosarcoma cells

Many tumors maintain chromosome-ends through a telomerase-independent, DNA-templated mechanism called alternative lengthening of telomeres (ALT). While ALT occurs in only a subset of tumors, it is strongly associated with mutations in the genes ATRX and DAXX, which encode components of an H3.3 histo...

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Detalles Bibliográficos
Autores principales: Yost, Kathryn E., Clatterbuck Soper, Sarah F., Walker, Robert L., Pineda, Marbin A., Zhu, Yuelin J., Ester, Corbin D., Showman, Soyeon, Roschke, Anna V., Waterfall, Joshua J., Meltzer, Paul S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418139/
https://www.ncbi.nlm.nih.gov/pubmed/30872698
http://dx.doi.org/10.1038/s41598-019-41058-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418139/
https://www.ncbi.nlm.nih.gov/pubmed/30872698
http://dx.doi.org/10.1038/s41598-019-41058-8

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