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The Post-Synaptic Function of Brca2

Homologous Recombination (HR) is a high-fidelity process with a range of biologic functions from generation of genetic diversity to repair of DNA double-strand breaks (DSBs). In mammalian cells, BRCA2 facilitates the polymerization of RAD51 onto ssDNA to form a presynaptic nucleoprotein filament. Th...

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Detalles Bibliográficos
Autores principales: Wang, Charles X., Jimenez-Sainz, Judit, Jensen, Ryan B., Mazin, Alexander V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418147/
https://www.ncbi.nlm.nih.gov/pubmed/30872704
http://dx.doi.org/10.1038/s41598-019-41054-y