Dual blockage of both PD-L1 and CD47 enhances immunotherapy against circulating tumor cells

Carcinoma metastasis is triggered by a subpopulation of circulating tumor cells (CTCs). And single immune checkpoint therapy is not good enough to inhibit CTC-induced metastasis. Here, we demonstrate that simultaneously blocking CD274 (programmed death ligand 1, PD-L1 or B7-H1) and CD47 checkpoints...

Descripción completa

Detalles Bibliográficos
Autores principales: Lian, Shu, Xie, Ruizhi, Ye, Yuying, Lu, Yusheng, Cheng, Yunlong, Xie, Xiaodong, Li, Shuhui, Jia, Lee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418176/
https://www.ncbi.nlm.nih.gov/pubmed/30872703
http://dx.doi.org/10.1038/s41598-019-40241-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418176/
https://www.ncbi.nlm.nih.gov/pubmed/30872703
http://dx.doi.org/10.1038/s41598-019-40241-1

Ejemplares similares