Disruption of CUL3-mediated ubiquitination causes proximal tubule injury and kidney fibrosis

Cullin 3 (CUL3) is part of the ubiquitin proteasomal system and controls several cellular processes critical for normal organ function including the cell cycle, and Keap1/Nrf2 signaling. Kidney tubule-specific Cul3 disruption causes tubulointerstitial fibrosis, but little is known about the mechanis...

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Detalles Bibliográficos
Autores principales: Saritas, Turgay, Cuevas, Catherina A., Ferdaus, Mohammed Z., Kuppe, Christoph, Kramann, Rafael, Moeller, Marcus J., Floege, Jürgen, Singer, Jeffrey D., McCormick, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418206/
https://www.ncbi.nlm.nih.gov/pubmed/30872636
http://dx.doi.org/10.1038/s41598-019-40795-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418206/
https://www.ncbi.nlm.nih.gov/pubmed/30872636
http://dx.doi.org/10.1038/s41598-019-40795-0

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