Aberrant Excitatory–Inhibitory Synaptic Mechanisms in Entorhinal Cortex Microcircuits During the Pathogenesis of Alzheimer’s Disease

Synaptic dysfunction is widely proposed as an initial insult leading to the neurodegeneration observed in Alzheimer’s disease (AD). We hypothesize that the initial insult originates in the lateral entorhinal cortex (LEC) due to deficits in key interneuronal functions and synaptic signaling mechanism...

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Detalles Bibliográficos
Autores principales: Petrache, Alexandra L, Rajulawalla, Aarib, Shi, Anqi, Wetzel, Andrea, Saito, Takashi, Saido, Takaomi C, Harvey, Kirsten, Ali, Afia B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418384/
https://www.ncbi.nlm.nih.gov/pubmed/30766992
http://dx.doi.org/10.1093/cercor/bhz016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418384/
https://www.ncbi.nlm.nih.gov/pubmed/30766992
http://dx.doi.org/10.1093/cercor/bhz016

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