Unanchored tri‐NEDD8 inhibits PARP‐1 to protect from oxidative stress‐induced cell death

NEDD8 is a ubiquitin‐like protein that activates cullin‐RING E3 ubiquitin ligases (CRLs). Here, we identify a novel role for NEDD8 in regulating the activity of poly(ADP‐ribose) polymerase 1 (PARP‐1) in response to oxidative stress. We show that treatment of cells with H(2)O(2) results in the accumu...

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Detalles Bibliográficos
Autores principales: Keuss, Matthew J, Hjerpe, Roland, Hsia, Oliver, Gourlay, Robert, Burchmore, Richard, Trost, Matthias, Kurz, Thimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418418/
https://www.ncbi.nlm.nih.gov/pubmed/30804002
http://dx.doi.org/10.15252/embj.2018100024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418418/
https://www.ncbi.nlm.nih.gov/pubmed/30804002
http://dx.doi.org/10.15252/embj.2018100024

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