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Unanchored tri‐NEDD8 inhibits PARP‐1 to protect from oxidative stress‐induced cell death
NEDD8 is a ubiquitin‐like protein that activates cullin‐RING E3 ubiquitin ligases (CRLs). Here, we identify a novel role for NEDD8 in regulating the activity of poly(ADP‐ribose) polymerase 1 (PARP‐1) in response to oxidative stress. We show that treatment of cells with H(2)O(2) results in the accumu...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418418/ https://www.ncbi.nlm.nih.gov/pubmed/30804002 http://dx.doi.org/10.15252/embj.2018100024 |