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Preformulation Studies of Furosemide-Loaded Electrospun Nanofibrous Systems for Buccal Administration

Furosemide loaded electrospun fibers were prepared for buccal administration, with the aim of improving the oral bioavailability of the poorly soluble and permeable crystalline drug, which can be achieved by the increased solubility and by the circumvention of the intensive first pass metabolism. Th...

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Autores principales: Kovács, Andrea, Démuth, Balázs, Meskó, Andrea, Zelkó, Romána
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418805/
https://www.ncbi.nlm.nih.gov/pubmed/30965943
http://dx.doi.org/10.3390/polym9120643
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author Kovács, Andrea
Démuth, Balázs
Meskó, Andrea
Zelkó, Romána
author_facet Kovács, Andrea
Démuth, Balázs
Meskó, Andrea
Zelkó, Romána
author_sort Kovács, Andrea
collection PubMed
description Furosemide loaded electrospun fibers were prepared for buccal administration, with the aim of improving the oral bioavailability of the poorly soluble and permeable crystalline drug, which can be achieved by the increased solubility and by the circumvention of the intensive first pass metabolism. The water soluble hydroxypropyl cellulose (HPC) was chosen as a mucoadhesive polymer. In order to improve the electrospinnability of HPC, poly (vinylpyrrolidone) (PVP) was used. During the experiments, the total polymer concentration was kept constant at 15% (w/w), and only the ratio of the two polymers (HPC-PVP = 5:5, 6:4, 7:3, 8:2, 9:1) was changed. A combination of rheological measurements with scanning electron microscopic morphological images of electrospun samples was applied for the determination of the optimum composition of the gels for fiber formation. The crystalline–amorphous transition of furosemide was tracked by Fourier transform infrared spectroscopy. A correlation was found between the rheological properties of the polymer solutions and their electrospinnability, and the consequent morphology of the resultant samples. With decreasing HPC ratio of the system, a transition from the spray-dried droplets to the randomly oriented fibrous structures was observed. The results enable the determination of the polymer ratio for the formation of applicable quality of electrospun fibers.
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spelling pubmed-64188052019-04-02 Preformulation Studies of Furosemide-Loaded Electrospun Nanofibrous Systems for Buccal Administration Kovács, Andrea Démuth, Balázs Meskó, Andrea Zelkó, Romána Polymers (Basel) Article Furosemide loaded electrospun fibers were prepared for buccal administration, with the aim of improving the oral bioavailability of the poorly soluble and permeable crystalline drug, which can be achieved by the increased solubility and by the circumvention of the intensive first pass metabolism. The water soluble hydroxypropyl cellulose (HPC) was chosen as a mucoadhesive polymer. In order to improve the electrospinnability of HPC, poly (vinylpyrrolidone) (PVP) was used. During the experiments, the total polymer concentration was kept constant at 15% (w/w), and only the ratio of the two polymers (HPC-PVP = 5:5, 6:4, 7:3, 8:2, 9:1) was changed. A combination of rheological measurements with scanning electron microscopic morphological images of electrospun samples was applied for the determination of the optimum composition of the gels for fiber formation. The crystalline–amorphous transition of furosemide was tracked by Fourier transform infrared spectroscopy. A correlation was found between the rheological properties of the polymer solutions and their electrospinnability, and the consequent morphology of the resultant samples. With decreasing HPC ratio of the system, a transition from the spray-dried droplets to the randomly oriented fibrous structures was observed. The results enable the determination of the polymer ratio for the formation of applicable quality of electrospun fibers. MDPI 2017-11-25 /pmc/articles/PMC6418805/ /pubmed/30965943 http://dx.doi.org/10.3390/polym9120643 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kovács, Andrea
Démuth, Balázs
Meskó, Andrea
Zelkó, Romána
Preformulation Studies of Furosemide-Loaded Electrospun Nanofibrous Systems for Buccal Administration
title Preformulation Studies of Furosemide-Loaded Electrospun Nanofibrous Systems for Buccal Administration
title_full Preformulation Studies of Furosemide-Loaded Electrospun Nanofibrous Systems for Buccal Administration
title_fullStr Preformulation Studies of Furosemide-Loaded Electrospun Nanofibrous Systems for Buccal Administration
title_full_unstemmed Preformulation Studies of Furosemide-Loaded Electrospun Nanofibrous Systems for Buccal Administration
title_short Preformulation Studies of Furosemide-Loaded Electrospun Nanofibrous Systems for Buccal Administration
title_sort preformulation studies of furosemide-loaded electrospun nanofibrous systems for buccal administration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418805/
https://www.ncbi.nlm.nih.gov/pubmed/30965943
http://dx.doi.org/10.3390/polym9120643
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