Letrozole treatment of adult female mice results in a similar reproductive phenotype but distinct changes in metabolism and the gut microbiome compared to pubertal mice

BACKGROUND: A majority of women with polycystic ovary syndrome (PCOS) have metabolic dysfunction that results in an increased risk of type 2 diabetes. We previously developed a pubertal mouse model using the aromatase inhibitor, letrozole, which recapitulates many of the reproductive and metabolic f...

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Detalles Bibliográficos
Autores principales: Torres, Pedro J., Skarra, Danalea V., Ho, Bryan S., Sau, Lillian, Anvar, Arya R., Kelley, Scott T., Thackray, Varykina G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419356/
https://www.ncbi.nlm.nih.gov/pubmed/30871463
http://dx.doi.org/10.1186/s12866-019-1425-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419356/
https://www.ncbi.nlm.nih.gov/pubmed/30871463
http://dx.doi.org/10.1186/s12866-019-1425-7

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