Loss of NF-κB p50 function synergistically augments microglial priming in the middle-aged brain

BACKGROUND: While NF-κB p50 function is impaired in central nervous system disease, aging in non-CNS tissues, and response to reactive oxygen species, the role of NF-κB p50 in aging-associated microglial pro-inflammatory priming is poorly understood. METHODS: Male NF-κB p50(+/+) and NF-κB p50(−/−) m...

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Detalles Bibliográficos
Autores principales: Taetzsch, Thomas, Benusa, Savannah, Levesque, Shannon, Mumaw, Christen L., Block, Michelle L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419422/
https://www.ncbi.nlm.nih.gov/pubmed/30871598
http://dx.doi.org/10.1186/s12974-019-1446-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419422/
https://www.ncbi.nlm.nih.gov/pubmed/30871598
http://dx.doi.org/10.1186/s12974-019-1446-z

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