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Loss of NF-κB p50 function synergistically augments microglial priming in the middle-aged brain
BACKGROUND: While NF-κB p50 function is impaired in central nervous system disease, aging in non-CNS tissues, and response to reactive oxygen species, the role of NF-κB p50 in aging-associated microglial pro-inflammatory priming is poorly understood. METHODS: Male NF-κB p50(+/+) and NF-κB p50(−/−) m...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419422/ https://www.ncbi.nlm.nih.gov/pubmed/30871598 http://dx.doi.org/10.1186/s12974-019-1446-z |