Antisense oligonucleotide targeting CD39 improves anti-tumor T cell immunity

BACKGROUND: Cancer cells are known to develop mechanisms to circumvent effective anti-tumor immunity. The two ectonucleotidases CD39 and CD73 are promising drug targets, as they act in concert to convert extracellular immune-stimulating ATP to adenosine. CD39 is expressed by different immune cell po...

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Detalles Bibliográficos
Autores principales: Kashyap, Abhishek S., Thelemann, Tamara, Klar, Richard, Kallert, Sandra M., Festag, Julia, Buchi, Melanie, Hinterwimmer, Lisa, Schell, Monika, Michel, Sven, Jaschinski, Frank, Zippelius, Alfred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419472/
https://www.ncbi.nlm.nih.gov/pubmed/30871609
http://dx.doi.org/10.1186/s40425-019-0545-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419472/
https://www.ncbi.nlm.nih.gov/pubmed/30871609
http://dx.doi.org/10.1186/s40425-019-0545-9

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