Pathogenic alpha-synuclein aggregates preferentially bind to mitochondria and affect cellular respiration

Misfolded alpha-synuclein (αSyn) is a major constituent of Lewy bodies and Lewy neurites, which are pathological hallmarks of Parkinson’s disease (PD). The contribution of αSyn to PD is well established, but the detailed mechanism remains obscure. Using a model in which αSyn aggregation in primary n...

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Detalles Bibliográficos
Autores principales: Wang, Xinhe, Becker, Katelyn, Levine, Nathan, Zhang, Michelle, Lieberman, Andrew P., Moore, Darren J., Ma, Jiyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419482/
https://www.ncbi.nlm.nih.gov/pubmed/30871620
http://dx.doi.org/10.1186/s40478-019-0696-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419482/
https://www.ncbi.nlm.nih.gov/pubmed/30871620
http://dx.doi.org/10.1186/s40478-019-0696-4

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