Cargando…

INC280 inhibits Wnt/β-catenin and EMT signaling pathways and its induce apoptosis in diffuse gastric cancer positive for c-MET amplification

OBJECTIVE: Gastric cancer is more open related to genetic predisposition. In our RNA sequencing study on gastric cancer patients, Runt-related transcription factor-3 (RUNX3) expression was significantly down-regulated in gastric cancer. We showed that decreased levels of RUNX3 are significantly asso...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sohn, Sung-Hwa, Kim, Bohyun, Sul, Hee Jung, Kim, Yoo Jin, Kim, Hyeong Su, Kim, Hongtae, Seo, Jong Bok, Koh, Youngho, Zang, Dae Young
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Note
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419497/ https://www.ncbi.nlm.nih.gov/pubmed/30871613 http://dx.doi.org/10.1186/s13104-019-4163-x

Ejemplares similares

Foretinib Inhibits Cancer Stemness and Gastric Cancer Cell Proliferation by Decreasing CD44 and c-MET Signaling
por: Sohn, Sung-Hwa, et al.
Publicado: (2020)

Responses to the Tepotinib in Gastric Cancers with MET Amplification or MET Exon 14 Skipping Mutations and High Expression of Both PD-L1 and CD44
por: Sohn, Sung-Hwa, et al.
Publicado: (2022)

INC280, an orally available small molecule inhibitor of c-MET, reduces migration and adhesion in ovarian cancer cell models
por: Moran-Jones, Kim, et al.
Publicado: (2015)

RNF43 R117fs mutant positively regulates Wnt/β-catenin signaling by failing to internalize FZD expressed on the cell surface
por: Cho, A-Ri, et al.
Publicado: (2022)

The effects of crizotinib in a transgenic Drosophila model expressing the human TPM4-ALK fusion gene or TPM4
por: Kim, Yoo Jin, et al.
Publicado: (2019)

Targeting cMET with INC280 impairs tumour growth and improves efficacy of gemcitabine in a pancreatic cancer model
por: Brandes, Franziska, et al.
Publicado: (2015)

A phase II study of the efficacy and safety of the MET inhibitor capmatinib (INC280) in patients with advanced hepatocellular carcinoma
por: Qin, Shukui, et al.
Publicado: (2019)

Tepotinib Inhibits the Epithelial–Mesenchymal Transition and Tumor Growth of Gastric Cancers by Increasing GSK3β, E-Cadherin, and Mucin 5AC and 6 Levels
por: Sohn, Sung-Hwa, et al.
Publicado: (2020)

TRK inhibitors block NFKB and induce NRF2 in TRK fusion-positive colon cancer
por: Sohn, Sung-Hwa, et al.
Publicado: (2021)

Erratum to A phase II study of the efficacy and safety of the MET inhibitor capmatinib (INC280) in patients with advanced hepatocellular carcinoma
Publicado: (2020)

Single low-dose INC280-loaded theranostic nanoparticles achieve multirooted delivery for MET-targeted primary and liver metastatic NSCLC
por: Sun, Yige, et al.
Publicado: (2022)

RNF43 and PWWP2B inhibit cancer cell proliferation and are predictive or prognostic biomarker for FDA-approved drugs in patients with advanced gastric cancer
por: Sohn, Sung-Hwa, et al.
Publicado: (2021)

Phase I dose‐escalation study of capmatinib (INC280) in Japanese patients with advanced solid tumors
por: Esaki, Taito, et al.
Publicado: (2019)

Entrectinib Induces Apoptosis and Inhibits the Epithelial–Mesenchymal Transition in Gastric Cancer with NTRK Overexpression
por: Sohn, Sung-Hwa, et al.
Publicado: (2021)

EMT and MET: necessary or permissive for metastasis?
por: Jolly, Mohit Kumar, et al.
Publicado: (2017)

A novel RIP1-mediated canonical WNT signaling pathway that promotes colorectal cancer metastasis via β -catenin stabilization-induced EMT
por: Kang, A-Ram, et al.
Publicado: (2023)

Induction of an EMT-like transformation and MET in vitro
por: Ding, Songming, et al.
Publicado: (2013)

Cell–cell adhesion: linking Wnt/β-catenin signaling with partial EMT and stemness traits in tumorigenesis
por: Basu, Sayon, et al.
Publicado: (2018)

SERPINH1 regulates EMT and gastric cancer metastasis via the Wnt/β-catenin signaling pathway
por: Tian, Shan, et al.
Publicado: (2020)

WNT/β-catenin pathway: A novel therapeutic target for attenuating airway remodelling and EMT in COPD
por: Eapen, Mathew Suji, et al.
Publicado: (2020)

Dihydroartemisinin suppresses proliferation, migration, the Wnt/β-catenin pathway and EMT via TNKS in gastric cancer
por: Ma, Yanmei, et al.
Publicado: (2021)

TIPE2 Inhibits Hypoxia-Induced Wnt/β-Catenin Pathway Activation and EMT in Glioma Cells
por: Liu, Zhi-jun, et al.
Publicado: (2016)

Dihydroartemisinin suppresses proliferation, migration, the Wnt/β-catenin pathway and EMT via TNKS in gastric cancer
por: Ma, Yanmei, et al.
Publicado: (2022)

Emerging Therapeutic Strategies for Attenuating Tubular EMT and Kidney Fibrosis by Targeting Wnt/β-Catenin Signaling
por: Hu, Lichao, et al.
Publicado: (2022)

ShenKang Injection Attenuates Renal Fibrosis by Inhibiting EMT and Regulating the Wnt/β-Catenin Pathway
por: Wei, Hui-Ting, et al.
Publicado: (2022)

CYP1B1 Enhances Cell Proliferation and Metastasis through Induction of EMT and Activation of Wnt/β-Catenin Signaling via Sp1 Upregulation
por: Kwon, Yeo-Jung, et al.
Publicado: (2016)

KY19382 Accelerates Cutaneous Wound Healing via Activation of the Wnt/β-Catenin Signaling Pathway
por: Yoon, Minguen, et al.
Publicado: (2023)

Hydrogen Sulfide Inhibits Transforming Growth Factor-β1-Induced EMT via Wnt/Catenin Pathway
por: Guo, Lin, et al.
Publicado: (2016)

SMARCAD1 Promotes Pancreatic Cancer Cell Growth and Metastasis through Wnt/β-catenin-Mediated EMT
por: Liu, Furao, et al.
Publicado: (2019)

RUNX1 promotes tumour metastasis by activating the Wnt/β-catenin signalling pathway and EMT in colorectal cancer
por: Li, Qingyuan, et al.
Publicado: (2019)

Sanguinarine suppresses migration and metastasis in colorectal carcinoma associated with the inversion of EMT through the Wnt/β‐catenin signaling
por: Zhu, Man, et al.
Publicado: (2020)

Silencing of KIF3B Suppresses Breast Cancer Progression by Regulating EMT and Wnt/β-Catenin Signaling
por: Wang, Chengqin, et al.
Publicado: (2021)

Demethylzelasteral inhibits proliferation and EMT via repressing Wnt/β-catenin signaling in esophageal squamous cell carcinoma
por: Yu, Jiarui, et al.
Publicado: (2021)

GPX2 predicts recurrence-free survival and triggers the Wnt/β-catenin/EMT pathway in prostate cancer
por: Yang, Ming, et al.
Publicado: (2022)

AKT-ions with a TWIST between EMT and MET
por: Tang, Huifang, et al.
Publicado: (2016)

Role of the Wnt/β-Catenin Pathway in Renal Osteodystrophy
por: Bisson, Sarah-Kim, et al.
Publicado: (2018)

The Wnt/β-catenin signaling pathway regulates the development of airway remodeling in patients with asthma
por: Kwak, Hyun Jung, et al.
Publicado: (2015)

A Phase Ib/II, open-label, multicenter study of INC280 (capmatinib) alone and in combination with buparlisib (BKM120) in adult patients with recurrent glioblastoma
por: van den Bent, Martin, et al.
Publicado: (2019)

IQGAP1 promotes pancreatic cancer progression and epithelial-mesenchymal transition (EMT) through Wnt/β-catenin signaling
por: Hu, Wei, et al.
Publicado: (2019)

Haemophilus parasuis Infection Disrupts Adherens Junctions and Initializes EMT Dependent on Canonical Wnt/β-Catenin Signaling Pathway
por: Hua, Kexin, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_724a9kcc8hcrtbcjedslb4nt2l