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Dichloroacetic acid upregulates apoptosis of ovarian cancer cells by regulating mitochondrial function

BACKGROUND: Metabolic reprogramming is a characteristic of tumor cells and is considered a potential therapeutic target. Even under aerobic conditions, tumor cells use glycolysis to produce energy, a phenomenon called the “Warburg effect”. Pyruvate dehydrogenase kinase 1 (PDK1) is a key factor linki...

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Detalles Bibliográficos
Autores principales: Zhou, Li, Liu, Lianlian, Chai, Wei, Zhao, Ting, Jin, Xin, Guo, Xinxin, Han, Liying, Yuan, Chunli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419601/
https://www.ncbi.nlm.nih.gov/pubmed/30881027
http://dx.doi.org/10.2147/OTT.S194329