Quantitative analysis of the effects of nicotinamide phosphoribosyltransferase induction on the rates of NAD(+) synthesis and breakdown in mammalian cells using stable isotope-labeling combined with mass spectrometry

NAD(+) is mainly synthesized from nicotinamide (Nam) by the rate-limiting enzyme Nam phosphoribosyltransferase (Nampt) and degraded to Nam by NAD(+)-degrading enzymes in mammals. Numerous studies report that tissue NAD(+) levels decrease during aging and age-related diseases and suggest that NAD(+)...

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Detalles Bibliográficos
Autores principales: Hara, Nobumasa, Osago, Harumi, Hiyoshi, Mineyoshi, Kobayashi-Miura, Mikiko, Tsuchiya, Mikako
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420012/
https://www.ncbi.nlm.nih.gov/pubmed/30875389
http://dx.doi.org/10.1371/journal.pone.0214000

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420012/
https://www.ncbi.nlm.nih.gov/pubmed/30875389
http://dx.doi.org/10.1371/journal.pone.0214000

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