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Quantitative analysis of the effects of nicotinamide phosphoribosyltransferase induction on the rates of NAD(+) synthesis and breakdown in mammalian cells using stable isotope-labeling combined with mass spectrometry
NAD(+) is mainly synthesized from nicotinamide (Nam) by the rate-limiting enzyme Nam phosphoribosyltransferase (Nampt) and degraded to Nam by NAD(+)-degrading enzymes in mammals. Numerous studies report that tissue NAD(+) levels decrease during aging and age-related diseases and suggest that NAD(+)...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420012/ https://www.ncbi.nlm.nih.gov/pubmed/30875389 http://dx.doi.org/10.1371/journal.pone.0214000 |