Induction of AMPK activation by N,N’-diarylurea FND-4b decreases growth and increases apoptosis in triple negative and estrogen-receptor positive breast cancers

PURPOSE: Triple negative breast cancer (TNBC) is the most lethal and aggressive subtype of breast cancer. AMP-activated protein kinase (AMPK) is a major energy regulator that suppresses tumor growth, and 1-(3-chloro-4-((trifluoromethyl)thio)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea (FND-4b) is a no...

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Detalles Bibliográficos
Autores principales: Johnson, Jeremy, Rychahou, Piotr, Sviripa, Vitaliy M., Weiss, Heidi L., Liu, Chunming, Watt, David S., Evers, B. Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420029/
https://www.ncbi.nlm.nih.gov/pubmed/30875375
http://dx.doi.org/10.1371/journal.pone.0209392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420029/
https://www.ncbi.nlm.nih.gov/pubmed/30875375
http://dx.doi.org/10.1371/journal.pone.0209392

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