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Modulation of allosteric coupling by mutations: from protein dynamics and packing to altered native ensembles and function
A large body of work has gone into understanding the effect of mutations on protein structure and function. Conventional treatments have involved quantifying the change in stability, activity and relaxation rates of the mutants with respect to the wild-type protein. However, it is now becoming incre...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420056/ https://www.ncbi.nlm.nih.gov/pubmed/30268910 http://dx.doi.org/10.1016/j.sbi.2018.09.004 |