GADD45A binds R-loops and recruits TET1 to CpG island promoters

R-loops are DNA:RNA hybrids enriched at CpG islands (CGIs), which can regulate chromatin states1–8. How R-loops are recognized and interpreted by specific epigenetic readers is unknown. Here we show that GADD45A (Growth Arrest and DNA Damage Protein 45A) directly binds to R-loops and mediates local...

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Detalles Bibliográficos
Autores principales: Arab, Khelifa, Karaulanov, Emil, Musheev, Michael, Trnka, Philipp, Schäfer, Andrea, Grummt, Ingrid, Niehrs, Christof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420098/
https://www.ncbi.nlm.nih.gov/pubmed/30617255
http://dx.doi.org/10.1038/s41588-018-0306-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420098/
https://www.ncbi.nlm.nih.gov/pubmed/30617255
http://dx.doi.org/10.1038/s41588-018-0306-6

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