KCC2 overexpression prevents the paradoxical seizure-promoting action of somatic inhibition

Although cortical interneurons are apparently well-placed to suppress seizures, several recent reports have highlighted a paradoxical role of perisomatic-targeting parvalbumin-positive (PV+) interneurons in ictogenesis. Here, we use an acute in vivo model of focal cortical seizures in awake behaving...

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Detalles Bibliográficos
Autores principales: Magloire, Vincent, Cornford, Jonathan, Lieb, Andreas, Kullmann, Dimitri M., Pavlov, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420604/
https://www.ncbi.nlm.nih.gov/pubmed/30874549
http://dx.doi.org/10.1038/s41467-019-08933-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420604/
https://www.ncbi.nlm.nih.gov/pubmed/30874549
http://dx.doi.org/10.1038/s41467-019-08933-4

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