Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation

PKM2 is a key metabolic enzyme central to glucose metabolism and energy expenditure. Multiple stimuli regulate PKM2’s activity through allosteric modulation and post-translational modifications. Furthermore, PKM2 can partner with KDM8, an oncogenic demethylase and enter the nucleus to serve as a HIF...

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Detalles Bibliográficos
Autores principales: Chen, Tsan-Jan, Wang, Hung-Jung, Liu, Jai-Shin, Cheng, Hsin-Hung, Hsu, Sheng-Chieh, Wu, Meng-Chen, Lu, Chien-Hung, Wu, Yu-Fang, Wu, Jing-Wen, Liu, Ying-Yuan, Kung, Hsing-Jien, Wang, Wen-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420622/
https://www.ncbi.nlm.nih.gov/pubmed/30911680
http://dx.doi.org/10.1038/s42003-019-0343-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420622/
https://www.ncbi.nlm.nih.gov/pubmed/30911680
http://dx.doi.org/10.1038/s42003-019-0343-4

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