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The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors
Poly-(ADP-ribose) polymerase inhibitors (PARPi) selectively kill breast and ovarian cancers with defects in homologous recombination (HR) caused by BRCA1/2 mutations. There is also clinical evidence for the utility of PARPi in breast and ovarian cancers without BRCA mutations, but the underlying mec...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420636/ https://www.ncbi.nlm.nih.gov/pubmed/30874560 http://dx.doi.org/10.1038/s41467-019-09232-8 |