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Silencing of maternal hepatic glucocorticoid receptor is essential for normal fetal development in mice

Excessive or chronic stress can lead to a variety of diseases due to aberrant activation of the glucocorticoid receptor (GR), a ligand activated transcription factor. Pregnancy represents a particular window of sensitivity in which excessive stress can have adverse outcomes, particularly on the deve...

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Detalles Bibliográficos
Autores principales: Quinn, Matthew A., McCalla, Amy, He, Bo, Xu, Xiaojiang, Cidlowski, John A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420645/
https://www.ncbi.nlm.nih.gov/pubmed/30911679
http://dx.doi.org/10.1038/s42003-019-0344-3