An update on advances in magnetic resonance imaging of multiple system atrophy

In this review, we describe how different neuroimaging tools have been used to identify novel MSA biomarkers, highlighting their advantages and limitations. First, we describe the main structural MRI changes frequently associated with MSA including the ‘hot cross-bun’ and ‘putaminal rim’ signs as we...

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Autores principales: Chelban, Viorica, Bocchetta, Martina, Hassanein, Sara, Haridy, Nourelhoda A., Houlden, Henry, Rohrer, Jonathan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420901/
https://www.ncbi.nlm.nih.gov/pubmed/30460448
http://dx.doi.org/10.1007/s00415-018-9121-3
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author Chelban, Viorica
Bocchetta, Martina
Hassanein, Sara
Haridy, Nourelhoda A.
Houlden, Henry
Rohrer, Jonathan D.
author_facet Chelban, Viorica
Bocchetta, Martina
Hassanein, Sara
Haridy, Nourelhoda A.
Houlden, Henry
Rohrer, Jonathan D.
author_sort Chelban, Viorica
collection PubMed
description In this review, we describe how different neuroimaging tools have been used to identify novel MSA biomarkers, highlighting their advantages and limitations. First, we describe the main structural MRI changes frequently associated with MSA including the ‘hot cross-bun’ and ‘putaminal rim’ signs as well as putaminal, pontine, and middle cerebellar peduncle (MCP) atrophy. We discuss the sensitivity and specificity of different supra- and infratentorial changes in differentiating MSA from other disorders, highlighting those that can improve diagnostic accuracy, including the MCP width and MCP/superior cerebellar peduncle (SCP) ratio on T1-weighted imaging, raised putaminal diffusivity on diffusion-weighted imaging, and increased T2* signal in the putamen, striatum, and substantia nigra on susceptibility-weighted imaging. Second, we focus on recent advances in structural and functional MRI techniques including diffusion tensor imaging (DTI), resting-state functional MRI (fMRI), and arterial spin labelling (ASL) imaging. Finally, we discuss new approaches for MSA research such as multimodal neuroimaging strategies and how such markers may be applied in clinical trials to provide crucial data for accurately selecting patients and to act as secondary outcome measures.
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spelling pubmed-64209012019-04-03 An update on advances in magnetic resonance imaging of multiple system atrophy Chelban, Viorica Bocchetta, Martina Hassanein, Sara Haridy, Nourelhoda A. Houlden, Henry Rohrer, Jonathan D. J Neurol Neurological Update In this review, we describe how different neuroimaging tools have been used to identify novel MSA biomarkers, highlighting their advantages and limitations. First, we describe the main structural MRI changes frequently associated with MSA including the ‘hot cross-bun’ and ‘putaminal rim’ signs as well as putaminal, pontine, and middle cerebellar peduncle (MCP) atrophy. We discuss the sensitivity and specificity of different supra- and infratentorial changes in differentiating MSA from other disorders, highlighting those that can improve diagnostic accuracy, including the MCP width and MCP/superior cerebellar peduncle (SCP) ratio on T1-weighted imaging, raised putaminal diffusivity on diffusion-weighted imaging, and increased T2* signal in the putamen, striatum, and substantia nigra on susceptibility-weighted imaging. Second, we focus on recent advances in structural and functional MRI techniques including diffusion tensor imaging (DTI), resting-state functional MRI (fMRI), and arterial spin labelling (ASL) imaging. Finally, we discuss new approaches for MSA research such as multimodal neuroimaging strategies and how such markers may be applied in clinical trials to provide crucial data for accurately selecting patients and to act as secondary outcome measures. Springer Berlin Heidelberg 2018-11-20 2019 /pmc/articles/PMC6420901/ /pubmed/30460448 http://dx.doi.org/10.1007/s00415-018-9121-3 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Neurological Update
Chelban, Viorica
Bocchetta, Martina
Hassanein, Sara
Haridy, Nourelhoda A.
Houlden, Henry
Rohrer, Jonathan D.
An update on advances in magnetic resonance imaging of multiple system atrophy
title An update on advances in magnetic resonance imaging of multiple system atrophy
title_full An update on advances in magnetic resonance imaging of multiple system atrophy
title_fullStr An update on advances in magnetic resonance imaging of multiple system atrophy
title_full_unstemmed An update on advances in magnetic resonance imaging of multiple system atrophy
title_short An update on advances in magnetic resonance imaging of multiple system atrophy
title_sort update on advances in magnetic resonance imaging of multiple system atrophy
topic Neurological Update
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420901/
https://www.ncbi.nlm.nih.gov/pubmed/30460448
http://dx.doi.org/10.1007/s00415-018-9121-3
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