An update on advances in magnetic resonance imaging of multiple system atrophy
In this review, we describe how different neuroimaging tools have been used to identify novel MSA biomarkers, highlighting their advantages and limitations. First, we describe the main structural MRI changes frequently associated with MSA including the ‘hot cross-bun’ and ‘putaminal rim’ signs as we...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420901/ https://www.ncbi.nlm.nih.gov/pubmed/30460448 http://dx.doi.org/10.1007/s00415-018-9121-3 |
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author | Chelban, Viorica Bocchetta, Martina Hassanein, Sara Haridy, Nourelhoda A. Houlden, Henry Rohrer, Jonathan D. |
author_facet | Chelban, Viorica Bocchetta, Martina Hassanein, Sara Haridy, Nourelhoda A. Houlden, Henry Rohrer, Jonathan D. |
author_sort | Chelban, Viorica |
collection | PubMed |
description | In this review, we describe how different neuroimaging tools have been used to identify novel MSA biomarkers, highlighting their advantages and limitations. First, we describe the main structural MRI changes frequently associated with MSA including the ‘hot cross-bun’ and ‘putaminal rim’ signs as well as putaminal, pontine, and middle cerebellar peduncle (MCP) atrophy. We discuss the sensitivity and specificity of different supra- and infratentorial changes in differentiating MSA from other disorders, highlighting those that can improve diagnostic accuracy, including the MCP width and MCP/superior cerebellar peduncle (SCP) ratio on T1-weighted imaging, raised putaminal diffusivity on diffusion-weighted imaging, and increased T2* signal in the putamen, striatum, and substantia nigra on susceptibility-weighted imaging. Second, we focus on recent advances in structural and functional MRI techniques including diffusion tensor imaging (DTI), resting-state functional MRI (fMRI), and arterial spin labelling (ASL) imaging. Finally, we discuss new approaches for MSA research such as multimodal neuroimaging strategies and how such markers may be applied in clinical trials to provide crucial data for accurately selecting patients and to act as secondary outcome measures. |
format | Online Article Text |
id | pubmed-6420901 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-64209012019-04-03 An update on advances in magnetic resonance imaging of multiple system atrophy Chelban, Viorica Bocchetta, Martina Hassanein, Sara Haridy, Nourelhoda A. Houlden, Henry Rohrer, Jonathan D. J Neurol Neurological Update In this review, we describe how different neuroimaging tools have been used to identify novel MSA biomarkers, highlighting their advantages and limitations. First, we describe the main structural MRI changes frequently associated with MSA including the ‘hot cross-bun’ and ‘putaminal rim’ signs as well as putaminal, pontine, and middle cerebellar peduncle (MCP) atrophy. We discuss the sensitivity and specificity of different supra- and infratentorial changes in differentiating MSA from other disorders, highlighting those that can improve diagnostic accuracy, including the MCP width and MCP/superior cerebellar peduncle (SCP) ratio on T1-weighted imaging, raised putaminal diffusivity on diffusion-weighted imaging, and increased T2* signal in the putamen, striatum, and substantia nigra on susceptibility-weighted imaging. Second, we focus on recent advances in structural and functional MRI techniques including diffusion tensor imaging (DTI), resting-state functional MRI (fMRI), and arterial spin labelling (ASL) imaging. Finally, we discuss new approaches for MSA research such as multimodal neuroimaging strategies and how such markers may be applied in clinical trials to provide crucial data for accurately selecting patients and to act as secondary outcome measures. Springer Berlin Heidelberg 2018-11-20 2019 /pmc/articles/PMC6420901/ /pubmed/30460448 http://dx.doi.org/10.1007/s00415-018-9121-3 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Neurological Update Chelban, Viorica Bocchetta, Martina Hassanein, Sara Haridy, Nourelhoda A. Houlden, Henry Rohrer, Jonathan D. An update on advances in magnetic resonance imaging of multiple system atrophy |
title | An update on advances in magnetic resonance imaging of multiple system atrophy |
title_full | An update on advances in magnetic resonance imaging of multiple system atrophy |
title_fullStr | An update on advances in magnetic resonance imaging of multiple system atrophy |
title_full_unstemmed | An update on advances in magnetic resonance imaging of multiple system atrophy |
title_short | An update on advances in magnetic resonance imaging of multiple system atrophy |
title_sort | update on advances in magnetic resonance imaging of multiple system atrophy |
topic | Neurological Update |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420901/ https://www.ncbi.nlm.nih.gov/pubmed/30460448 http://dx.doi.org/10.1007/s00415-018-9121-3 |
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