CRISPR-Cas9 Mediated RNase L Knockout Regulates Cellular Function of PK-15 Cells and Increases PRV Replication

Ribonuclease L (RNase L) is an important antiviral endoribonuclease regulated by type I IFN. RNase L is activated by viral infection and dsRNA. Because the role of swine RNase L (sRNase L) is not fully understood, in this study, we generated a sRNase L knockout PK-15 (KO-PK) cell line through the CR...

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Detalles Bibliográficos
Autores principales: Sui, Chao, Jiang, Dandan, Wu, Xiangju, Cong, Xiaoyan, Li, Feng, Shang, Yingli, Wang, Jinqiu, Liu, Sidang, Shan, Hu, Qi, Jing, Du, Yijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421005/
https://www.ncbi.nlm.nih.gov/pubmed/30941371
http://dx.doi.org/10.1155/2019/7398208

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421005/
https://www.ncbi.nlm.nih.gov/pubmed/30941371
http://dx.doi.org/10.1155/2019/7398208

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