OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug

Drugs that reverse epigenetic silencing, such as the DNA methyltransferase inhibitor (DNMTi) 5-azacytidine (AZA), have profound effects on transcription and tumor cell survival. AZA is an approved drug for myelodysplastic syndromes and acute myeloid leukemia, and is under investigation for different...

Descripción completa

Detalles Bibliográficos
Autores principales: Banerjee, Shuvojit, Gusho, Elona, Gaughan, Christina, Dong, Beihua, Gu, Xiaorong, Holvey-Bates, Elise, Talukdar, Manisha, Li, Yize, Weiss, Susan R., Sicheri, Frank, Saunthararajah, Yogen, Stark, George R., Silverman, Robert H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421468/
https://www.ncbi.nlm.nih.gov/pubmed/30814222
http://dx.doi.org/10.1073/pnas.1815071116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421468/
https://www.ncbi.nlm.nih.gov/pubmed/30814222
http://dx.doi.org/10.1073/pnas.1815071116

Ejemplares similares