Discovery of Soft-Drug Topical Tool Modulators of Sphingosine-1-phosphate Receptor 1 (S1PR1)

[Image: see text] In order to study the role of S1PRs in inflammatory skin disease, S1PR modulators are dosed orally and topically in animal models of disease. The topical application of S1PR modulators in these models may, however, lead to systemic drug concentrations, which can complicate interpre...

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Detalles Bibliográficos
Autores principales: Bell, Mark, Foley, David, Naylor, Claire, Wood, Gavin, Robinson, Colin, Riley, Jennifer, Epemolu, Ola, Ellis, Lucy, Scullion, Paul, Shishikura, Yoko, Osuna-Cabello, Maria, Ferguson, Liam, Pinto, Erika, Fletcher, Daniel, Katz, Elad, McLean, W. H. Irwin, Wyatt, Paul, Read, Kevin D, Woodland, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421539/
https://www.ncbi.nlm.nih.gov/pubmed/30891137
http://dx.doi.org/10.1021/acsmedchemlett.8b00616

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421539/
https://www.ncbi.nlm.nih.gov/pubmed/30891137
http://dx.doi.org/10.1021/acsmedchemlett.8b00616

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