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Atorvastatin (Lipitor) by MCR
[Image: see text] A concise and convergent synthesis of the atorvastatin, the best-selling cardiovascular drug of all time, is presented. Our approach is based on an Ugi reaction, which shortens the current synthetic route and is advantageous over the published syntheses.
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421582/ https://www.ncbi.nlm.nih.gov/pubmed/30891146 http://dx.doi.org/10.1021/acsmedchemlett.8b00579 |
| _version_ | 1783404253339975680 |
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| author | Zarganes-Tzitzikas, Tryfon Neochoritis, Constantinos G. Dömling, Alexander |
| author_facet | Zarganes-Tzitzikas, Tryfon Neochoritis, Constantinos G. Dömling, Alexander |
| author_sort | Zarganes-Tzitzikas, Tryfon |
| collection | PubMed |
| description | [Image: see text] A concise and convergent synthesis of the atorvastatin, the best-selling cardiovascular drug of all time, is presented. Our approach is based on an Ugi reaction, which shortens the current synthetic route and is advantageous over the published syntheses. |
| format | Online Article Text |
| id | pubmed-6421582 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | American Chemical
Society |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-64215822019-03-19 Atorvastatin (Lipitor) by MCR Zarganes-Tzitzikas, Tryfon Neochoritis, Constantinos G. Dömling, Alexander ACS Med Chem Lett [Image: see text] A concise and convergent synthesis of the atorvastatin, the best-selling cardiovascular drug of all time, is presented. Our approach is based on an Ugi reaction, which shortens the current synthetic route and is advantageous over the published syntheses. American Chemical Society 2019-02-07 /pmc/articles/PMC6421582/ /pubmed/30891146 http://dx.doi.org/10.1021/acsmedchemlett.8b00579 Text en Copyright © 2019 American Chemical Society This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License (http://pubs.acs.org/page/policy/authorchoice_ccbyncnd_termsofuse.html) , which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes. |
| spellingShingle | Zarganes-Tzitzikas, Tryfon Neochoritis, Constantinos G. Dömling, Alexander Atorvastatin (Lipitor) by MCR |
| title | Atorvastatin (Lipitor) by MCR |
| title_full | Atorvastatin (Lipitor) by MCR |
| title_fullStr | Atorvastatin (Lipitor) by MCR |
| title_full_unstemmed | Atorvastatin (Lipitor) by MCR |
| title_short | Atorvastatin (Lipitor) by MCR |
| title_sort | atorvastatin (lipitor) by mcr |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421582/ https://www.ncbi.nlm.nih.gov/pubmed/30891146 http://dx.doi.org/10.1021/acsmedchemlett.8b00579 |
| work_keys_str_mv | AT zarganestzitzikastryfon atorvastatinlipitorbymcr AT neochoritisconstantinosg atorvastatinlipitorbymcr AT domlingalexander atorvastatinlipitorbymcr |