Assembly of transgenic human P301S Tau is necessary for neurodegeneration in murine spinal cord

A pathological pathway leading from soluble monomeric to insoluble filamentous Tau is characteristic of many human neurodegenerative diseases, which also exhibit dysfunction and death of brain cells. However, it is unknown how the assembly of Tau into filaments relates to cell loss. To study this, w...

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Detalles Bibliográficos
Autores principales: Macdonald, Jennifer A., Bronner, Iraad F., Drynan, Lesley, Fan, Juan, Curry, Annabelle, Fraser, Graham, Lavenir, Isabelle, Goedert, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421678/
https://www.ncbi.nlm.nih.gov/pubmed/30885267
http://dx.doi.org/10.1186/s40478-019-0695-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421678/
https://www.ncbi.nlm.nih.gov/pubmed/30885267
http://dx.doi.org/10.1186/s40478-019-0695-5

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