Single-molecule nascent RNA sequencing reveals regulatory domain architecture at promoters and enhancers

Eukaryotic RNA Polymerase II has been found at both promoters and distal enhancers, suggesting additional functions beyond mRNA production. To understand this role, we sequenced nascent RNAs at single-molecule resolution to unravel the interplay between Pol2 initiation, capping, and pausing genome-w...

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Detalles Bibliográficos
Autores principales: Tome, Jacob M., Tippens, Nathaniel D., Lis, John T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422046/
https://www.ncbi.nlm.nih.gov/pubmed/30349116
http://dx.doi.org/10.1038/s41588-018-0234-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422046/
https://www.ncbi.nlm.nih.gov/pubmed/30349116
http://dx.doi.org/10.1038/s41588-018-0234-5

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