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Single-molecule nascent RNA sequencing reveals regulatory domain architecture at promoters and enhancers
Eukaryotic RNA Polymerase II has been found at both promoters and distal enhancers, suggesting additional functions beyond mRNA production. To understand this role, we sequenced nascent RNAs at single-molecule resolution to unravel the interplay between Pol2 initiation, capping, and pausing genome-w...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422046/ https://www.ncbi.nlm.nih.gov/pubmed/30349116 http://dx.doi.org/10.1038/s41588-018-0234-5 |